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KMID : 0363320120330020160
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 2 p.160 ~ p.171
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Overview of the Interaction between Warfarin and Korean Herbal Medicine
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Lee In
Park Sang-Moo
Park Seung-Chan
Kim Do-Hyung
Cho Min-Kyoung
Han Chang-Woo
Kwon Jung-Nam
Hong Jin-Woo
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Abstract
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Background and Objective: Warfarin is the standard anticoagulation treatment for atrial fibrillation, venous thromboembolism (VTE), and mechanical heart valves. Close monitoring of the International Normalized Ratio (INR) is required due to the drug’s very narrow therapeutic window. Many factors can affect INR levels. Drug and food interactions are frequently cited as causes of adverse events with warfarin. We discussed interactions between herbs and warfarin studied in this research.
Methods: In this review, PubMed was used to search medical journals. Keywords "warfarin AND interaction" were applied.
Results: 55 articles were included. The possibility of correlation between warfarin and single herbal medicines such as Salviae Miltiorrhizae Radix, Angelicae Gigantis Radix, Ginseng Radix Alba, Lycii Fructus, Ginkgo Folium, Menthae Herba, Trigonellae semen was suggested. Furthermore, some herbal compounds interacting with warfarin were reported. The conclusion of studies reporting the effect of herbal medicine on warfarin were controversial due to small size or quality of research.
Conclusions: We suggest that we should prescribe therapeutic herbal medicines to patients using warfarin more carefully and do INR follow-up regularly.
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KEYWORD
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warfarin, herbal medicine, interaction
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